Two compartment model
- 2 discrete phases
- 1st phase(blue): Rapid decrease in concentration
- Represents Distribution
- 2nd phase(green): Slower decrease in concentration
- Represents extrapolated Elimination
- Elimination also begins immediately after the drug is administered, but it contributes a small decrease
—Distribution
—Elimination
—Hybrid Rate Constant, actual concentration of drug in plasma
Barash, Paul G, Bruce F. Cullen, and Robert K. Stoelting. Clinical Anesthesia. Philadelphia: Lippincott, 1989.